Global landscape and regulatory principles of DNA methylation reprogramming for germ cell specification by mouse pluripotent stem cells
K Shirane, K Kurimoto, Y Yabuta, M Yamaji, J Satoh… - Developmental cell, 2016 - cell.com
Specification of primordial germ cells (PGCs) activates epigenetic reprogramming for
totipotency, the elucidation of which remains a fundamental challenge. Here, we uncover …
totipotency, the elucidation of which remains a fundamental challenge. Here, we uncover …
The dynamics of genome-wide DNA methylation reprogramming in mouse primordial germ cells
Genome-wide DNA methylation reprogramming occurs in mouse primordial germ cells
(PGCs) and preimplantation embryos, but the precise dynamics and biological outcomes are …
(PGCs) and preimplantation embryos, but the precise dynamics and biological outcomes are …
Comparative principles of DNA methylation reprogramming during human and mouse in vitro primordial germ cell specification
F von Meyenn, RV Berrens, S Andrews, F Santos… - Developmental cell, 2016 - cell.com
Primordial germ cell (PGC) development is characterized by global epigenetic remodeling,
which resets genomic potential and establishes an epigenetic ground state. Here we …
which resets genomic potential and establishes an epigenetic ground state. Here we …
Prdm14 promotes germline fate and naive pluripotency by repressing FGF signalling and DNA methylation
Primordial germ cells (PGCs) and somatic cells originate from postimplantation epiblast cells
in mice. As pluripotency is lost upon differentiation of somatic lineages, a naive epigenome …
in mice. As pluripotency is lost upon differentiation of somatic lineages, a naive epigenome …
[HTML][HTML] Epiblast stem cell-based system reveals reprogramming synergy of germline factors
A Gillich, S Bao, N Grabole, K Hayashi, MWB Trotter… - Cell stem cell, 2012 - cell.com
Epigenetic reprogramming in early germ cells is critical toward the establishment of
totipotency, but investigations of the germline events are intractable. An objective cell culture …
totipotency, but investigations of the germline events are intractable. An objective cell culture …
Germline DNA demethylation dynamics and imprint erasure through 5-hydroxymethylcytosine
Mouse primordial germ cells (PGCs) undergo sequential epigenetic changes and genome-
wide DNA demethylation to reset the epigenome for totipotency. Here, we demonstrate that …
wide DNA demethylation to reset the epigenome for totipotency. Here, we demonstrate that …
A unique gene regulatory network resets the human germline epigenome for development
Resetting of the epigenome in human primordial germ cells (hPGCs) is critical for
development. We show that the transcriptional program of hPGCs is distinct from that in …
development. We show that the transcriptional program of hPGCs is distinct from that in …
Naive pluripotency is associated with global DNA hypomethylation
Naive pluripotent embryonic stem cells (ESCs) and embryonic germ cells (EGCs) are
derived from the preimplantation epiblast and primordial germ cells (PGCs), respectively …
derived from the preimplantation epiblast and primordial germ cells (PGCs), respectively …
Parallel mechanisms of epigenetic reprogramming in the germline
JA Hackett, JJ Zylicz, MA Surani - Trends in Genetics, 2012 - cell.com
Germ cells possess the extraordinary and unique capacity to give rise to a new organism
and create an enduring link between all generations. To acquire this property, primordial …
and create an enduring link between all generations. To acquire this property, primordial …
Specification and epigenetic programming of the human germ line
Primordial germ cells (PGCs), the precursors of sperm and eggs, are established in
perigastrulation-stage embryos in mammals. Signals from extra-embryonic tissues induce a …
perigastrulation-stage embryos in mammals. Signals from extra-embryonic tissues induce a …