[PDF][PDF] Divergent whole-genome methylation maps of human and chimpanzee brains reveal epigenetic basis of human regulatory evolution
DNA methylation is a pervasive epigenetic DNA modification that strongly affects chromatin
regulation and gene expression. To date, it remains largely unknown how patterns of DNA …
regulation and gene expression. To date, it remains largely unknown how patterns of DNA …
Comparative methylome analyses identify epigenetic regulatory loci of human brain evolution
How do epigenetic modifications change across species and how do these modifications
affect evolution? These are fundamental questions at the forefront of our evolutionary …
affect evolution? These are fundamental questions at the forefront of our evolutionary …
A genome-wide study of DNA methylation patterns and gene expression levels in multiple human and chimpanzee tissues
The modification of DNA by methylation is an important epigenetic mechanism that affects
the spatial and temporal regulation of gene expression. Methylation patterns have been …
the spatial and temporal regulation of gene expression. Methylation patterns have been …
Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood
Background Dynamic changes to the epigenome play a critical role in establishing and
maintaining cellular phenotype during differentiation, but little is known about the normal …
maintaining cellular phenotype during differentiation, but little is known about the normal …
Population-specificity of human DNA methylation
Background Ethnic differences in human DNA methylation have been shown for a number of
CpG sites, but the genome-wide patterns and extent of these differences are largely …
CpG sites, but the genome-wide patterns and extent of these differences are largely …
Dynamics of DNA methylation in recent human and great ape evolution
I Hernando-Herraez, J Prado-Martinez, P Garg… - PLoS …, 2013 - journals.plos.org
DNA methylation is an epigenetic modification involved in regulatory processes such as cell
differentiation during development, X-chromosome inactivation, genomic imprinting and …
differentiation during development, X-chromosome inactivation, genomic imprinting and …
The interplay between DNA methylation and sequence divergence in recent human evolution
I Hernando-Herraez, H Heyn… - Nucleic acids …, 2015 - academic.oup.com
Despite the increasing knowledge about DNA methylation, the understanding of human
epigenome evolution is in its infancy. Using whole genome bisulfite sequencing we …
epigenome evolution is in its infancy. Using whole genome bisulfite sequencing we …
Role of CpG context and content in evolutionary signatures of brain DNA methylation
Y Xin, AH O'Donnell, Y Ge, B Chanrion, M Milekic… - Epigenetics, 2011 - Taylor & Francis
DNA methylation is essential in brain function and behavior; therefore, understanding the
role of DNA methylation in brain-based disorders begins with the study of DNA methylation …
role of DNA methylation in brain-based disorders begins with the study of DNA methylation …
Neurons show distinctive DNA methylation profile and higher interindividual variations compared with non-neurons
Epigenome information in mammalian brain cells reflects their developmental history,
neuronal activity, and environmental exposures. Studying the epigenetic modifications …
neuronal activity, and environmental exposures. Studying the epigenetic modifications …
Evolution of DNA methylation in the human brain
DNA methylation is a critical regulatory mechanism implicated in development, learning,
memory, and disease in the human brain. Here we have elucidated DNA methylation …
memory, and disease in the human brain. Here we have elucidated DNA methylation …