Background DNA methylation is a contributing factor to both rare and common human
diseases, and plays a major role in development and gene silencing. While the variation of …

Understanding the diversity of human tissues is fundamental to disease and requires linking
genetic information, which is identical in most of an individual's cells, with epigenetic …

Background Cytosine DNA methylation is a heritable epigenetic mark present in most
eukaryotic groups. While the patterns and functions of DNA methylation have been …

In spite of intense interest in how altered epigenetic processes including DNA methylation
may contribute to psychiatric and neurodevelopmental disorders, there is a limited …

Epigenetic modifications confer stable transcriptional patterns in the brain, and both normal
and abnormal brain function involve specialized brain regions. We examined DNA …

The possibility that alterations in DNA methylation are mechanistic drivers of development,
aging and susceptibility to disease is widely acknowledged, but evidence remains patchy or …

Background DNA methylation is a major epigenetic modification important for regulating
gene expression and suppressing spurious transcription. Most methods to scan the genome …

The mammalian genome depends on patterns of methylated cytosines for normal function,
but the relationship between genomic methylation patterns and the underlying sequence is …

Methylation of cytosines is an essential epigenetic modification in mammalian genomes, yet
the rules that govern methylation patterns remain largely elusive. To gain insights into this …

DNA methylation in the genome plays a fundamental role in the regulation of gene
expression and is widespread in the genome of eukaryotic species. For example, in higher …