A fundamental initiative for evolutionary biologists is to understand the molecular basis
underlying phenotypic diversity. A long-standing hypothesis states that species-specific traits …

Cytosine DNA methylation is essential in brain development and is implicated in various
neurological disorders. Understanding DNA methylation diversity across the entire brain in a …

Epigenetic mechanisms traditionally have been studied in the domains of development and
disease, but they may also play important roles in ecological and evolutionary processes. In …

Previously published comparative functional genomic data sets from primates using frozen
tissue samples, including many data sets from our own group, were often collected and …

Epigenetics refers to heritable phenotypic alterations in the absence of DNA sequence
changes, and DNA methylation is one of the extensively studied epigenetic alterations. DNA …

Mammalian brain cells show remarkable diversity in gene expression, anatomy and
function, yet the regulatory DNA landscape underlying this extensive heterogeneity is poorly …

The DNA methylation landscape is dynamically patterned during development and distinct
methylation patterns distinguish healthy from diseased cells. However, whether tissue …

Understanding how the epigenetic blueprint of the genome shapes human phenotypes
requires systematic evaluation of the complex interplay between gene activity and the …

DNA methylation is a tightly regulated epigenetic mark associated with transcriptional
repression. Next-generation sequencing of purified methylated DNA obtained from early …

Given the tissue-specific nature of epigenetic processes, the assessment of disease-relevant
tissue is an important consideration for epigenome-wide association studies (EWAS). Little …