DNA methylation constitutes an important epigenetic regulation mechanism in many
eukaryotes, although the extent of DNA methylation in the regulation of gene expression in …

DNA methylation is a class of epigenetic modification essential for coordinating gene
expression timing and magnitude throughout normal brain development and for proper brain …

Background Early life is a period of drastic epigenetic remodeling in which the epigenome is
especially sensitive to extrinsic and intrinsic influence. However, the epigenome-wide …

Multiple recent studies highlight that genetic variants can have strong impacts on a
significant proportion of the human DNA methylome. Methylation quantitative trait loci, or …

In mammals, DNA methylation profiles vary substantially between tissues. Recent genome-
scale studies report that blood displays a highly distinctive methylomic profile from other …

DNA methylation is one of the most extensively studied epigenetic marks. It is involved in
transcriptional gene silencing and plays important roles during mammalian development. Its …

Parent-of-origin effects (POE) exist when there is differential expression of alleles inherited
from the two parents. A genome-wide scan for POE on DNA methylation at 639,238 CpGs in …

In plants and mammals, DNA methylation plays a critical role in transcriptional silencing by
delineating heterochromatin from transcriptionally active euchromatin. A homeostatic …

Background The functional impact of genetic variation has been extensively surveyed,
revealing that genetic changes correlated to phenotypes lie mostly in non-coding genomic …

Parent-specific differentially methylated regions (DMRs) are established during
gametogenesis and regulate parent-specific expression of imprinted genes. Monoallelic …