Copy number of the mitochondrial DNA of leucocytes as an aging marker and risk factors for the development of age-related diseases in humans
VN Maximov, SK Malyutina, PS Orlov… - Advances in …, 2020 - Springer
The mitochondrial DNA (mtDNA) copy number was analyzed via quantitative real-time PCR.
A random subset of 996 people was studied (437 men with an average age of 67.3±7.2 …
A random subset of 996 people was studied (437 men with an average age of 67.3±7.2 …
Associations between cell-free mitochondrial DNA and inflammation, and their clinical implications for patients on hemodialysis: a prospective multicenter cohort study
Background: Cell-free mitochondrial DNA (cf-mtDNA) has recently been in the spotlight as
an endogenously produced danger molecule that can potentially elicit inflammation …
an endogenously produced danger molecule that can potentially elicit inflammation …
[HTML][HTML] The association between mitochondrial DNA abundance and stroke: a combination of multivariable-adjusted survival and Mendelian randomization analyses
Background and aims Mitochondrial dysfunction is associated with increased reactive
oxygen species (ROS) that are thought to drive disease risk, including stroke. We …
oxygen species (ROS) that are thought to drive disease risk, including stroke. We …
Platelet mtDNA content and leukocyte count influence whole blood mtDNA content
Abstract Changes in whole blood (WB) mitochondrial DNA (mtDNA) content are associated
with health and disease. Platelet-derived mtDNA can confound WB mtDNA content …
with health and disease. Platelet-derived mtDNA can confound WB mtDNA content …
Circulating cell-free mitochondrial DNA in brain health and disease: A systematic review and meta-analysis
Objectives Circulating cell-free mitochondrial DNA (ccf-mtDNA) are detectable fragments of
mtDNA released from the cell as a result of mitochondrial dysfunction or apoptosis. The …
mtDNA released from the cell as a result of mitochondrial dysfunction or apoptosis. The …
[HTML][HTML] Molecular and bioenergetic differences between cells with African versus European inherited mitochondrial DNA haplogroups: implications for population …
MC Kenney, M Chwa, SR Atilano… - … et Biophysica Acta (BBA …, 2014 - Elsevier
The geographic origins of populations can be identified by their maternally inherited
mitochondrial DNA (mtDNA) haplogroups. This study compared human cybrids (cytoplasmic …
mitochondrial DNA (mtDNA) haplogroups. This study compared human cybrids (cytoplasmic …
Mitochondrial DNA sequence variants associated with blood pressure among 2 cohorts of older adults
Background Age‐related changes in blood pressure are associated with a variety of poor
health outcomes. Genetic factors are proposed contributors to age‐related increases in …
health outcomes. Genetic factors are proposed contributors to age‐related increases in …
[HTML][HTML] Baseline mitochondrial DNA copy number and heart failure incidence and its role in overall and heart failure mortality in middle-aged women
K Sundquist, J Sundquist, X Wang, K Palmer… - Frontiers in …, 2022 - frontiersin.org
Heart failure (HF) is a leading cause of death in both men and women. However, risk factors
seem to differ for men and women and significant gaps in sex-specific knowledge exist …
seem to differ for men and women and significant gaps in sex-specific knowledge exist …
Association of mitochondrial DNA copy number with brain MRI markers and cognitive function: a meta-analysis of community-based cohorts
Background and Objectives Previous studies suggest that lower mitochondrial DNA
(mtDNA) copy number (CN) is associated with neurodegenerative diseases. However …
(mtDNA) copy number (CN) is associated with neurodegenerative diseases. However …
Mitochondrial DNA copy number and incident heart failure: the atherosclerosis risk in communities (ARIC) study
CORRESPONDENCE survival model with separate spline variables for baseline hazard and
for time-dependent effects. All statistical analyses were performed using Stata version 15.0 …
for time-dependent effects. All statistical analyses were performed using Stata version 15.0 …