DNA methylation is highly dynamic during mammalian embryogenesis. It is broadly
accepted that the paternal genome is actively depleted of 5-methylcytosine at fertilization …

Putting the DNA back into DNA methylation | Nature Genetics Skip to main content Thank you
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DNA methylation is a crucial element in the epigenetic regulation of mammalian embryonic
development,,,,. However, its dynamic patterns have not been analysed at the genome scale …

The germline is the only cellular lineage capable of transferring genetic information from one
generation to the next. Intergenerational transmission of epigenetic memory through the …

Epigenetic processes (eg, DNA methylation) have been proposed as potentially important
evolutionary mechanisms. However, before drawing conclusions about their evolutionary …

Twin studies have provided the basis for genetic and epidemiological studies in human
complex traits,. As epigenetic factors can contribute to phenotypic outcomes, we conducted …

Epigenetic reprogramming of parental genomes following fertilization is important to ensure
compatibility for totipotency and development thereafter. New studies by Jiang et al. and …

DNA methylation is the most stable type of epigenetic modification modulating the
transcriptional plasticity of mammalian genomes. Using bisulfite DNA sequencing, we report …

DNA cytosine methylation is a central epigenetic modification that has essential roles in
cellular processes including genome regulation, development and disease. Here we …

DNA methylation is a dynamic process through which specific chromatin modifications can
be stably transmitted from parent to daughter cells. A large body of work has suggested that …