DNA methylation is of paramount importance for mammalian embryonic development. DNA
methylation has numerous functions: it is implicated in the repression of transposons and …

DNA methylation (5mC) is a repressive gene regulatory mark widespread in vertebrate
genomes, yet the developmental dynamics in which 5mC patterns are established vary …

Mouse embryos acquire global DNA methylation of their genome during implantation.
However the exact roles of DNA methyltransferases (DNMTs) in embryos have not been …

DNA methylation is a critical epigenetic regulator of development in mammals and social
insects, but its significance in development outside these groups is not understood. Here we …

Eukaryotic cytosine methylation represses transcription but also occurs in the bodies of
active genes, and the extent of methylation biology conservation is unclear. We quantified …

DNA methylation plays a vital role in tissue development and differentiation in eukaryotes.
Epigenetic studies have been seldom conducted in the extremely diverse and evolutionarily …

Alterations in DNA methylation (DNAm) in cancer have been known for 25 years, including
hypomethylation of oncogenes and hypermethylation of tumor suppressor genes 1 …

Epigenetic mechanisms generate plastic phenotypes that can become locally adapted
across environments. Disentangling genomic from epigenomic variation is challenging in …

Recent discourse concerning the mode of inheritance of germline epimutations has
centered on whether the altered epigenetic state may be passed directly through the …

Epigenetic mechanisms traditionally have been studied in the domains of development and
disease, but they may also play important roles in ecological and evolutionary processes. In …