DNA methylation is a heritable epigenetic mark found in a wide range of eukaryotes. By
mapping DNA methylation within the majority of human promoters, the authors of a new …

In addition to genetic variation, epigenetic mechanisms such as DNA methylation might
make important contributions to heritable phenotypic diversity in populations. However, it is …

Major evolutionary transitions are enigmas, and the most notable enigma is between
invertebrates and vertebrates, with numerous spectacular innovations. To search for the …

Background DNA methylation is an epigenetic mechanism with important regulatory
functions in animals. While the mechanism itself is evolutionarily ancient, the distribution and …

The question of whether DNA methylation contributes to the stabilization of gene expression
patterns in differentiated mammalian tissues remains controversial. Using genome-wide …

DNA methylation is a vital epigenetic mark that participates in establishing and maintaining
chromatin structures and regulates gene transcription during mammalian development and …

Genomes of invertebrates and vertebrates exhibit highly divergent patterns of DNA
methylation. Invertebrate genomes tend to be sparsely methylated, and DNA methylation is …

DNA methylation is generally limited to CpG doublets located at the gene promoter with an
involvement in gene silencing. Surprisingly, two recent papers showed an extensive …

Opinion Dunwell & Pfeifer proteins which in humans are known to use 5mC as a substrate
[1]. These are somewhat conflicting ideas, an enzyme that uses 5mC as a substrate, but no …

It is widely accepted that the epigenome can act as the link between environmental cues,
both external and internal, to the organism and phenotype by converting the environmental …