Enhancer of zeste 2 (Ezh2), a SET domain-containing protein, is crucial for development in
many model organisms, including early mouse development. In mice, Ezh2 is detected as a …

Through the histone methyltransferase EZH2, the Polycomb complex PRC2 mediates
H3K27me3 and is associated with transcriptional repression. PRC2 regulates cell-fate …

The H3K27 histone methyltransferase, Ezh2 (enhancer of zeste 2), is a Polycomb group
protein that plays important roles in many biological processes including cellular …

Enhancer of zeste homologue 2 (EZH2) is the catalytic subunit of Polycomb repressive
complex 2 that catalyzes the trimethylation of histone H3 on Lys 27, and represses gene …

Abstract Polycomb-group (Pc-G) genes are required for the stable repression of the
homeotic selector genes and other developmentally regulated genes, presumably through …

Epigenetic regulation plays an important role in stem cell self-renewal, maintenance and
lineage differentiation. The epigenetic profiles of stem cells are related to their transcriptional …

Histone methylation plays an important role in chromatin dynamics and gene expression.
Methylation of histone H3-lysine 27 by the EZH2 complex has been linked to the silencing of …

Abstract Background Embryonal Rhabdomyosarcoma (RMS) is a pediatric soft-tissue
sarcoma derived from myogenic precursors that is characterized by a good prognosis in …

The Polycomb group proteins are involved in maintenance of the silenced state of several
developmentally regulated genes. These proteins form large aggregates with different …

Genetic variants in chromatin regulators are frequently found in neurodevelopmental
disorders, but their effect in disease etiology is rarely determined. Here, we uncover and …