Thyroid stimulating hormone (TSH) hormone levels are normally tightly regulated within an
individual; thus, relatively small variations may indicate thyroid disease. Genome-wide …

Objective Common variants in PDE8B are associated with TSH but apparently without any
effect on thyroid hormone levels that is difficult to explain. Furthermore, the stability of the …

Thyroid hormone is essential for normal metabolism and development, and overt
abnormalities in thyroid function lead to common endocrine disorders affecting …

We repurposed existing genotypes in DNA biobanks across the Electronic Medical Records
and Genomics network to perform a genome-wide association study for primary …

Background Hypothyroidism is associated with obesity, and thyroid hormones are involved
in the regulation of body composition, including fat mass. Genome-wide association studies …

Objective Minor variation in serum thyroid hormone (TH) levels can have important effects
on various clinical endpoints. Although 45–65% of the inter-individual variation in serum TH …

Thyroid-stimulating hormone (TSH) controls thyroid growth and hormone secretion through
binding to its G protein-coupled receptor (TSHR) and production of cyclic AMP (cAMP) …

Thyroid hormones play a critical role in regulation of multiple physiological functions and
thyroid dysfunction is associated with substantial morbidity. Here, we use electronic health …

Thyroid hormones play key roles in cellular growth, development and metabolism. Although
there is a strong genetic influence on thyroid hormone levels, the genes involved are widely …

Thyroid-stimulating hormone (TSH) is a sensitive indicator of thyroid function. High and low
TSH levels reflect hypothyroidism and hyperthyroidism, respectively. Even within the normal …