Measurement of OEF and absolute CMRO2: MRI-based methods using interleaved and combined hypercapnia and hyperoxia
Blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI)
is most commonly used in a semi-quantitative manner to infer changes in brain activity …
is most commonly used in a semi-quantitative manner to infer changes in brain activity …
Sources of systematic bias in hypercapnia-calibrated functional MRI estimation of oxygen metabolism
The change in cerebral rate of oxidative metabolism (CMRO2) during neural activation may
be estimated from blood oxygenation level-dependent (BOLD) functional magnetic …
be estimated from blood oxygenation level-dependent (BOLD) functional magnetic …
Mapping oxidative metabolism in the human brain with calibrated fMRI in health and disease
JJ Chen, B Uthayakumar… - Journal of Cerebral Blood …, 2022 - journals.sagepub.com
Conventional functional MRI (fMRI) with blood-oxygenation level dependent (BOLD)
contrast is an important tool for mapping human brain activity non-invasively. Recent interest …
contrast is an important tool for mapping human brain activity non-invasively. Recent interest …
Global cerebral oxidative metabolism during hypercapnia and hypocapnia in humans: implications for BOLD fMRI
The effect of carbon dioxide (CO2) on cerebral metabolism is of tremendous interest to
functional imaging. In particular, mild-to-moderate hypercapnia is routinely used in …
functional imaging. In particular, mild-to-moderate hypercapnia is routinely used in …
[HTML][HTML] Measurement of oxygen extraction fraction (OEF): An optimized BOLD signal model for use with hypercapnic and hyperoxic calibration
A Merola, K Murphy, AJ Stone, MA Germuska… - Neuroimage, 2016 - Elsevier
Several techniques have been proposed to estimate relative changes in cerebral metabolic
rate of oxygen consumption (CMRO 2) by exploiting combined BOLD fMRI and cerebral …
rate of oxygen consumption (CMRO 2) by exploiting combined BOLD fMRI and cerebral …
[HTML][HTML] Interpreting oxygenation-based neuroimaging signals: the importance and the challenge of understanding brain oxygen metabolism
R Buxton - Frontiers in neuroenergetics, 2010 - frontiersin.org
Functional magnetic resonance imaging (fMRI) is widely used to map patterns of brain
activation based on blood oxygenation level dependent (BOLD) signal changes associated …
activation based on blood oxygenation level dependent (BOLD) signal changes associated …
[HTML][HTML] Dual-calibrated fMRI measurement of absolute cerebral metabolic rate of oxygen consumption and effective oxygen diffusivity
M Germuska, HL Chandler, RC Stickland, C Foster… - Neuroimage, 2019 - Elsevier
Dual-calibrated fMRI is a multi-parametric technique that allows for the quantification of the
resting oxygen extraction fraction (OEF), the absolute rate of cerebral metabolic oxygen …
resting oxygen extraction fraction (OEF), the absolute rate of cerebral metabolic oxygen …
Magnetic resonance imaging of resting OEF and CMRO2 using a generalized calibration model for hypercapnia and hyperoxia
CJ Gauthier, RD Hoge - Neuroimage, 2012 - Elsevier
We present a method allowing determination of resting cerebral oxygen metabolism
(CMRO2) from MRI and end-tidal O2 measurements acquired during a pair of respiratory …
(CMRO2) from MRI and end-tidal O2 measurements acquired during a pair of respiratory …
Improved fMRI calibration: precisely controlled hyperoxic versus hypercapnic stimuli
The calibration of functional magnetic resonance imaging (fMRI) for the estimation of
neuronal activation-induced changes in cerebral metabolic rate of oxygen (CMRO2) has …
neuronal activation-induced changes in cerebral metabolic rate of oxygen (CMRO2) has …
Investigation of BOLD signal dependence on cerebral blood flow and oxygen consumption: the deoxyhemoglobin dilution model
RD Hoge, J Atkinson, B Gill, GR Crelier… - … in Medicine: An …, 1999 - Wiley Online Library
The relationship between blood oxygenation level‐dependent (BOLD) MRI signals, cerebral
blood flow (CBF), and oxygen consumption (CMRO2) in the physiological steady state was …
blood flow (CBF), and oxygen consumption (CMRO2) in the physiological steady state was …