Changes in cerebral blood flow (CBF), volume (CBV), and oxygenation (blood-oxygenation
level dependent (BOLD)) during functional activation are important for calculating changes …

Investigations into the blood oxygenation level-dependent (BOLD) functional MRI signal
have used respiratory challenges with the aim of probing cerebrovascular physiology. Such …

The brain depends almost entirely on oxidative metabolism to meet its significant energy
requirements. As such, the cerebral metabolic rate of oxygen (CMRO2) represents a key …

After its discovery in 1990, blood oxygenation level-dependent (BOLD) contrast in functional
magnetic resonance imaging (fMRI) has been widely used to map brain activation in …

We present a technique for quantifying global cerebral metabolic rate of oxygen
consumption (CMRO2) in absolute physiologic units at 3-second temporal resolution and …

Abstract Although BOLD functional MRI (fMRI) provides a useful tool for probing neuronal
activities, large intersubject variations in signal amplitude are commonly observed …

Cerebral blood flow (CBF) and oxygenation changes following both a simple breath holding
test (BHT) and a CO2 challenge can be detected with functional magnetic resonance …

The blood oxygenation level‐dependent (BOLD) effect in functional magnetic resonance
imaging depends on at least partial uncoupling between cerebral blood flow (CBF) and …

Baseline hematocrit fraction (Hct) is a determinant for baseline cerebral blood flow (CBF)
and between‐subject variation of Hct thus causes variation in task‐based BOLD fMRI signal …

New MRI methods for noninvasive imaging of baseline oxygen extraction fraction (OEF) in
the brain show great promise. Quantitative O 2 imaging (QUO2) applies a biophysical model …