Pharmacokinetics varies widely between children. Many factors play an important role in this
variability, such as ontogeny, pharmacogenetics, gender, comorbidities, and drug-drug …

From birth, children may need to take medication for acute or chronic diseases. Antibiotics,
anti-asthmatic drugs, antihistamines, analgesics, gastrointestinal drugs and attention …

A paucity of data exists on the disposition and effect of drugs in young children. This
information gap can be reduced by elucidating developmental principles of absorption …

Cytochrome P450 (CYP) enzymes are commonly involved in drug metabolism, and genetic
variation in the genes encoding CYPs are associated with variable drug response. While …

Cytochrome P450 monooxygenases catalyze the metabolism of approximately 40-60% of
widely used drugs with a A6986G CYP3A5 polymorphism determining expresser (A6986 …

The cytochromes P450 comprise a family of enzymes that are responsible for around three-
quarters of all drug metabolism reactions that occur in human populations. Many isoforms of …

The current use and future perspectives of molecular genetic characterisation of cytochrome
P450 enzymes (CYP) for drug development and drug treatment are summarised. CYP …

Members of the human cytochrome P450 (CYP) superfamily play a role in the metabolism of
many drugs and several of them, CYP2D6, CYP2C9 and CYP2C19, have been shown to be …

The cytochrome P450 superfamily (CYP450) in humans is formed by 57 functional
monooxygenases critical for the metabolism of numerous endogenous and exogenous …

Pharmacogenetics affects both pharmacokinetics and pharmacodynamics, thereby
influencing an individual's response to drugs, both in terms of response and adverse …