Important interindividual differences in drug pharmacokinetics cause absence of drug
response or adverse drug reactions in significant fractions of the populations. The …

The cytochrome P450 (CYP) enzyme family catalyses the metabolism of approximately 80%
of all medications. 1, 2 Many genes encoding the CYP enzymes exhibit high levels of …

Considerable progress has been made in pharmacogenetics over the past decade, resulting
in increased awareness and availability of pharmacogenetic diagnostics in the clinical …

For 50 years, pharmacogenetics has been studying the genetic basis for variability in drug
response between individual patients, both with respect to drug toxicity and drug efficacy …

Cytochrome P450 enzymes (CYP) play a pivot role in phase I of xenobiotic
biotransformation. Many of CYP enzymes are known to be polymorphic, with many allelic …

Editorial Thirumaran, Heck & Hocum the remaining 66%[4]. Genelex internal data suggest
that of the total DDIs 13% are cDDIs. More recently, a retrospective analysis of more than …

Genetic variations in the genes encoding the cytochrome P450s (CYPs) are important
determinants for interindividual differences in sensitivity to drugs and environmental …

Genetic polymorphisms of cytochrome P450 (CYP) enzymes are one of the factors that
contribute to the pharmacokinetic (PK) variability of drugs. PK variability is observed in the …

Background: The polymorphic cytochrome P450 isoenzymes CYP2C9 and CYP2C19 are
involved in the biotransformation of a wide variety of clinical drugs. Their major alleles occur …

Abstract Background and Objective Phenotyping cocktails use a combination of cytochrome
P450 (CYP)-specific probe drugs to simultaneously assess the activity of different CYP …