The three-way connection between DNA methylation, gene activity and chromatin structure
has been known for almost two decades. Nevertheless, the molecular link between methyl …

DNA methylation and chromatin modification are two global mechanisms that regulate gene
expression. Recent studies provide insight into the mechanism of transcriptional silencing by …

DNA methylation and chromatin modification operate along a common pathway to repress
transcription; accordingly, several experiments demonstrate that the effects of DNA …

Histone deacetylation plays an important role in methylated DNA silencing. Recent studies
indicated that the methyl-CpG-binding protein, MBD2, is a component of the MeCP1 histone …

Methylation of cytosine at CpG dinucleotides is a common feature of many higher eukaryotic
genomes. A major biological consequence of DNA methylation is gene silencing. Increasing …

DNA methylation plays an important role in mammalian development and correlates with
chromatin-associated gene silencing. The recruitment of MeCP2 to methylated CpG …

MeCP2 is a transcription factor that recognizes and binds symmetrically methylated CpG
dinucleotides to repress transcription. MeCP2 can associate with the Sin3a/histone …

A correlation between DNA methylation and transcriptional silencing has existed for many
years. Recently, substantial progress has been reported in the search for proteins that …

CpG methylation is known to suppress transcription. This repression is generally thought to
be related to alterations of chromatin structure that are specified by the methylation. The …

During mammalian cell division, DNA methylation patterns are transferred accurately to the
newly synthesized DNA strand. This depends on maintenance DNA methyltransferase …