Combination therapy with atorvastatin and amlodipine suppresses angiotensin II-induced aortic aneurysm formation
K Takahashi, Y Matsumoto, Z Do. e, M Kanazawa… - PloS one, 2013 - journals.plos.org
Background Abdominal aortic aneurysm (AAA) is a life-threatening vascular disease. It is
controversial whether statin and calcium channel blockers (CCBs) has an inhibitory effect on …
controversial whether statin and calcium channel blockers (CCBs) has an inhibitory effect on …
Simvastatin inhibits angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-knockout mice: possible role of ERK
Y Zhang, JC Naggar, CM Welzig… - … , and vascular biology, 2009 - Am Heart Assoc
Objective—Abdominal aortic aneurysm (AAA) is a life-threatening disease affecting almost
10% of the population over age 65. Generation of AAAs by infusion of angiotensin (Ang) II in …
10% of the population over age 65. Generation of AAAs by infusion of angiotensin (Ang) II in …
[HTML][HTML] Pravastatin activates activator protein 2 alpha to augment the angiotensin II-induced abdominal aortic aneurysms
H Ma, WJ Liang, MR Shan, XQ Wang, SN Zhou… - Oncotarget, 2017 - ncbi.nlm.nih.gov
We have previously reported that activation of AMP-activated kinase alpha 2 (AMPKa2) by
nicotine or angiotensin II (AngII) instigates formation of abdominal aortic aneurysms (AAA) in …
nicotine or angiotensin II (AngII) instigates formation of abdominal aortic aneurysms (AAA) in …
Inhibition of endoplasmic reticulum stress signaling pathway: a new mechanism of statins to suppress the development of abdominal aortic aneurysm
Y Li, G Lu, D Sun, H Zuo, DW Wang, J Yan - PloS one, 2017 - journals.plos.org
Background Abdominal aortic aneurysm (AAA) is a potentially lethal disease with extremely
poor survival rates once the aneurysm ruptures. Statins may exert beneficial effects on the …
poor survival rates once the aneurysm ruptures. Statins may exert beneficial effects on the …
[HTML][HTML] Hypercholesterolemia accelerates both the initiation and progression of angiotensin II-induced abdominal aortic aneurysms
Objective: This study determined whether hypercholesterolemia would contribute to both the
initiation and progression of angiotensin (Ang) II-induced abdominal aortic aneurysms …
initiation and progression of angiotensin (Ang) II-induced abdominal aortic aneurysms …
[HTML][HTML] Inhibition of angiotensin-induced aortic aneurysm by metformin in apolipoprotein E–deficient mice
A Kunath, J Unosson, M Friederich-Persson… - JVS-vascular …, 2021 - Elsevier
Objective Metformin is associated with a reduced incidence and growth of abdominal aortic
aneurysms (AAAs). The aim of the present study was to investigate the inhibitory effects of …
aneurysms (AAAs). The aim of the present study was to investigate the inhibitory effects of …
Efficacy of simvastatin in reducing aortic dilatation in mouse models of abdominal aortic aneurysm
Purpose Currently there is no effective drug therapy for abdominal aortic aneurysm (AAA).
The aim of this study was to assess the ability of simvastatin to inhibit aortic dilatation in two …
The aim of this study was to assess the ability of simvastatin to inhibit aortic dilatation in two …
Statins exert differential effects on angiotensin II-induced atherosclerosis, but no benefit for abdominal aortic aneurysms
OBJECTIVE: Statins reduce atherosclerosis, but it is controversial whether they suppress
abdominal aortic aneurysm (AAA) expansion. We hypothesized that statins (rosuvastatin …
abdominal aortic aneurysm (AAA) expansion. We hypothesized that statins (rosuvastatin …
Short-term 20-mg atorvastatin therapy reduces key inflammatory factors including c-Jun N-terminal kinase and dendritic cells and matrix metalloproteinase expression …
K Kajimoto, K Miyauchi, T Kasai, K Shimada, Y Kojima… - Atherosclerosis, 2009 - Elsevier
BACKGROUND: Abdominal aortic aneurysm (AAA) accumulates features of a chronic
inflammatory disorder and irreversible destruction of connective tissue. A recent …
inflammatory disorder and irreversible destruction of connective tissue. A recent …
Statins: the holy grail of Abdominal Aortic Aneurysm (AAA) growth attenuation? A systematic review of the literature
JA Dunne, MA Bailey, KJ Griffin… - Current vascular …, 2014 - ingentaconnect.com
Background: In the era of Abdominal Aortic Aneurysm (AAA) screening, pharmacotherapies
to attenuate AAA growth are sought. HMG Co-A reductase inhibitors (statins) have …
to attenuate AAA growth are sought. HMG Co-A reductase inhibitors (statins) have …