Because each cell type has a unique epigenome to help provide cell specificity, the use of a
mixed cell population in the analysis of DNA methylation is a reflection of all cell types …

In recent years, the field of epigenetics has grown dramatically and has become one of the
most dynamic and fast-growing branches of molecular biology. The amount of diseases …

DNA methylation has been viewed as a stable component of the epigenome, which is
established during development and fixed thereafter. We show here using nearest neighbor …

DNA methylation of CpGs located in two types of repetitive elements—LINE1 (L1) and Alu—
is used to assess “global” changes in DNA methylation in studies of human disease and …

Genomic DNA methylation is a major epigenetic mechanism controlling the expression of
genetic information. Therefore, identifying regions of the genome that are differentially …

The establishment of a cell identification method more accurate than the conventional
morphological and cell-type-specific marker analyses has been desired. DNA methylation is …

Objective To study peripheral blood DNA differential methylation in oligozoospermic infertile
men in comparison with normozoospermic fertile controls. Design Case-control study …

Male infertility is a complex, multifactorial, and heterogeneous condition. In 15% of couples,
infertility results from an identifiable genetic defect. However, in 40% of couples, male …

DNA methylation has been proposed to be important in many biological processes and is
the subject of intense study. Traditional bisulfite genomic sequencing allows detailed high …

Extensive epigenetic reprogramming occurs during mammalian gametogenesis and
preimplantation development. DNA methylation patterns that are laid down during these …