Background Assisted reproductive technology (ART) might induce adverse pregnancy
outcomes and increase the risk of metabolic diseases in offspring'later life with unknown …

A large number of studies have documented the methylation patterns of individual genes
and repeated sequences in different tissues of various mammalian species. This has …

Epigenetics refers to heritable phenotypic alterations in the absence of DNA sequence
changes, and DNA methylation is one of the extensively studied epigenetic alterations. DNA …

In mammals, DNA methylation profiles vary substantially between tissues. Recent genome-
scale studies report that blood displays a highly distinctive methylomic profile from other …

For the first time, DNA methylation patterns in the human cytotrophoblast and the
extraembryonic mesoderm were determined using a genome-wide Infinium …

DNA methylation is known to be associated with cell differentiation, aging, disease and
cancer. There exists an expanding base of knowledge regarding tissue-specific DNA …

Epigenetic variation is increasingly hypothesized as a mechanism underlying the effect of
the in utero environment on long-term postnatal health; however, there is currently little clear …

Methylation of DNA, which occurs at cytosines of CpG sequences, is a unique chemical
modification of the vertebrate genome. Methylation patterns can be copied to daughter DNA …

STUDY QUESTION Do methylation changes in sperm DNA correlate with infertility? STUDY
ANSWER Loss of spermatogenesis and fertility was correlated with 1680 differentially …

The aim of this project was to develop a simple screening tool to measure the DNA
methylation of fibroblast cells, and to determine if differences in DNA methylation could be …