Recently, differences in DNA methylation patterns in placental and umbilical blood samples
taken from children born after IVF and children conceived naturally have been reported …

Biermann and Steger N Epigenetics in Male Germ Cells 467 fertility; as in Dnmt3L2/2 mice,
pachytene spermatocytes exhibit homologous chromosomes that fail to align and form …

Previous reports have shown that DNA methylation profiles within primary human malignant
tissues are altered when these cells are transformed into cancer cell lines. However, it is …

Background Single-cell transcriptome and single-cell methylome technologies have become
powerful tools to study RNA and DNA methylation profiles of single cells at a genome-wide …

Epigenetic factors such as DNA methylation are DNA alterations affecting gene expression
that can convey environmental information through generations. Only a few studies have …

Epigenetics represents a secondary inheritance system that has been poorly investigated in
human biology. The objective of this study was to perform a comprehensive analysis of DNA …

With the rapid development of genome-wide high-throughput technologies, including
expression arrays, SNP arrays and next-generation sequencing platforms, enormous …

Blood represents an easily accessible human tissue for numerous research and clinical
applications, including surrogate roles for biomarkers of other tissues. Dried blood spots …

We introduce a Bayesian semi-supervised method for estimating cell counts from DNA
methylation by leveraging an easily obtainable prior knowledge on the cell-type composition …

The haploid human genome contains approximately 29 million CpGs that exist in a
methylated, hydroxymethylated or unmethylated state, collectively referred to as the DNA …