We introduce a Bayesian semi-supervised method for estimating cell counts from DNA
methylation by leveraging an easily obtainable prior knowledge on the cell-type composition …

Epigenetic processes form the principal mechanisms by which cell differentiation occurs.
Consequently, DNA methylation measurements are strongly influenced by the DNA …

Background Single-cell transcriptome and single-cell methylome technologies have become
powerful tools to study RNA and DNA methylation profiles of single cells at a genome-wide …

DNA methylation is one of the mechanisms for the epigenetic control of gene expression.
Alterations in the methylation status of genomic DNA can result in the silencing of genes …

Epidemiological data indicate that children conceived in vitro have a greater relative risk of
low birth-weight, major and minor birth defects, and rare disorders involving imprinted …

Epigenetics can be defined as the study of heritable changes in gene expression without
alteration of the DNA sequence itself. This means that epigenetic variants are stable …

Genome-wide association studies in the fields of reproductive medicine and endocrinology
are yielding robust genetic variants associated with disease. Integrated genomic …

DNA methylation is an important epigenetic modification that undergoes dynamic changes
in mammalian embryogenesis, during which both parental genomes are reprogrammed …

Sex biases in the genome-wide distribution of DNA methylation and gene expression levels
are some of the manifestations of sexual dimorphism in mammals. To advance our …

Simple Summary Cancer cell lines are a defined population of cells, originally sourced from
tumour tissue, that can be maintained in culture for an extended period of time. They are a …