The epigenomes of mammalian sperm and oocytes, characterized by gamete-specific 5-
methylcytosine (5mC) patterns, are reprogrammed during early embryogenesis to establish …

The inheritance of epigenetic marks, in particular DNA methylation, provides a molecular
memory that ensures faithful commitment to transcriptional programs during mammalian …

DNA methylation at cytosine residues in CpG dinucleotides is a component of epigenetic
marks crucial to mammalian development. In preimplantation stage embryos, a large part of …

Epigenetic modifications established during gametogenesis regulate transcription and other
nuclear processes in gametes, but also have influences in the zygote, embryo and postnatal …

The first crucial step in the developmental program occurs during pre-implantation, the time
after the oocyte has been fertilized and before the embryo implants in the uterus. This period …

Global demethylation is part of a conserved program of epigenetic reprogramming to naive
pluripotency. The transition from primed hypermethylated embryonic stem cells (ESCs) to …

DNA methylation patterns are set up in a relatively fixed programmed manner during normal
embryonic development and are then stably maintained. Using genome-wide analysis, we …

Background DNA methylomes are extensively reprogrammed during mouse pre-
implantation and early germ cell development. The main feature of this reprogramming is a …

Epigenetic modification of the cytosine base of DNA by its methylation introduced the
possibility that beyond the inherent information contained within the nucleotide sequence …

Virtually all mammalian species including mouse, rat, pig, cow, and human, but not sheep
and rabbit, undergo genome‐wide epigenetic reprogramming by demethylation of the male …