During differentiation and development cells undergo dramatic morphological and functional
changes without any change in the DNA sequence. The underlying changes of gene …

Abstract In mammals, DNA 5-hydroxymethylcytosine (5hmC) is involved in methylation
reprogramming during early embryonic development. Yet, to what extent 5hmC participates …

DNA methylation is essential to development and cellular physiology in mammals. Faulty
DNA methylation is frequently observed in human diseases like cancer and neurological …

Identifying loci with parental differences in DNA methylation is key to unraveling parent-of-
origin phenotypes. By conducting a MeDIP-Seq screen in maternal-methylation free …

In mammals the genome is shaped by epigenetic regulation to manifest numerous cellular
identities. The term epigenetics has been used to refer to changes in gene expression …

DNA methylation is among the best studied epigenetic modifications and is essential to
mammalian development. Although the methylation status of most CpG dinucleotides in the …

Epigenetic information in the mammalian oocyte has the potential to be transmitted to the
next generation and influence gene expression; this occurs naturally in the case of imprinted …

Epigenetic reprogramming of the parental genomes upon fertilization is required for proper
embryonic development. It has long been appreciated that asymmetric distribution of histone …