Self-splicing proteins, called inteins, are present in many human pathogens, including the
emerging fungal threats Cryptococcus neoformans (Cne) and Cryptococcus gattii (Cga), the …

Inteins are self-splicing intervening sequences in proteins, and inteins of pathogenic
organisms can be attractive drug targets. Here, we report an intein in important fungal …

The Prp8 intein is one of the most widespread eukaryotic inteins, present in important
pathogenic fungi, including Cryptococcus and Aspergillus species. Because the processed …

As the Cne PRP8 intein is active and exists in an essential gene of an important fungal
pathogen, inhibitors of splicing and assays for intein activity are of interest. The self-splicing …

Drug resistance is a significant concern in the treatment of diseases, including
cryptococcosis caused by Cryptococcus neoformans (Cne) and Cryptococcus gattii (Cga) …

Multidrug-resistant pathogens are of significant concern in recent years. Hence new
antifungal and anti-bacterial drug targets are urgently needed before the situation goes …

Inteins are intervening sequences that are transcribed and translated with flanking host
protein sequences and then self-excised by protein splicing. Bi-functional inteins also …

Mycobacterium tuberculosis harbors three protein splicing elements, called inteins, in critical
genes and their protein products. Post-translational removal of the inteins occurs …

The spliceosome is a large ribonucleoprotein complex that removes introns from pre-
mRNAs. At its functional core lies the essential pre-mRNA processing factor 8 (Prp8) protein …

Inteins are self-splicing polypeptides with an ability to excise themselves from flanking host
protein regions with remarkable precision; in the process, they ligate flanked host protein …