Epigenetic modification of the cytosine base of DNA by its methylation introduced the
possibility that beyond the inherent information contained within the nucleotide sequence …

DNA methylation acts in concert with other epigenetic mechanisms to regulate normal gene
expression and facilitate chromatin organization within cells. Aberrant DNA methylation …

DNA methylation, or the covalent addition of a methyl group to cytosine within the context of
the CpG dinucleotide, has profound effects on the mammalian genome. These effects …

Background Myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are
neoplastic disorders of hematopoietic stem cells. DNA methyltransferase inhibitors, 5 …

Gains and losses in DNA methylation are prominent features of mammalian cell types. To
gain insight into the mechanisms that promote shifts in DNA methylation and contribute to …

DNA methylation is a significant regulator of gene expression, and its role in carcinogenesis
recently has been a subject of remarkable interest. The aim of this review is to analyze the …

The term epigenetics refers to the study of heritable changes in phenotype or expression of
genes that are not due to changes in the sequence of DNA. 1 Research into epigenetics has …

During the past few decades we have witnessed an era of remarkable growth in the field of
molecular biology. In 1950 very little was known of the chemical constitution of biological …

Intense interest in the biological roles of DNA methylation, particularly in eukaryotes, has
produced at least eight different methods for identifying 5-methylcytosine and related …

The aim of pharmacology has traditionally been to develop compounds that could mimic,
activate or antagonize the molecules that control and regulate the physiological state of an …