Characterizing the effect of oxygen (O2) modulation on the brain may provide a better
understanding of several clinically relevant problems, including acute mountain sickness …

Background and Purpose—A noninvasive MRI method to measure cerebral oxygen
metabolism has the potential to assess tissue viability during cerebral ischemia. The …

Hypoxic hypoxia (inspiratory hypoxia) stimulates an increase in cerebral blood flow (CBF)
maintaining oxygen delivery to the brain. However, this response, particularly at the tissue …

Blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI)
is most commonly used in a semi-quantitative manner to infer changes in brain activity …

We have recently described an extension of calibrated MRI, which we term QUO2 (for
QUantitative O2 imaging), providing absolute quantification of resting oxidative metabolism …

Many brain diseases have been linked to abnormal oxygen metabolism and blood
perfusion; nevertheless, there is still a lack of robust diagnostic tools for directly imaging …

Functional magnetic resonance imaging (fMRI) is widely used to map patterns of brain
activation based on blood oxygenation level dependent (BOLD) signal changes associated …

Measuring the global cerebral metabolic rate of oxygen (CMRO 2) is a valuable tool for
assessing brain vitality and function. Measurement of blood oxygen saturation (HbO 2) and …

The cerebral cortex has a number of conserved morphological and functional characteristics
across brain regions and species. Among them, the laminar differences in microvascular …

Graded levels of supplemental inspired oxygen were investigated for their viability as a
noninvasive method of obtaining intravascular magnetic resonance image contrast …