Existing microarray-based approaches for screening of DNA methylation are hampered by a
number of shortcomings, such as the introduction of bias by DNA copy-number imbalances …

Medulloblastoma arises in the cerebellum and is the most common malignant brain tumour
of childhood, however its molecular basis is not well understood. To assess the role of …

Candidate gene investigations have indicated a significant role for epigenetic events in the
pathogenesis of medulloblastoma, the most common malignant brain tumor of childhood. To …

Medulloblastomas exhibit an array of diverse cytogenetic abnormalities. To evaluate the
significance of epigenetic rather than genetic lesions in medulloblastomas and other …

DNA methylation might have a significant role in preventing normal differentiation in
pediatric cancers. We used a genomewide method for detecting regions of CpG methylation …

Neuroblastoma is a very heterogeneous tumor of childhood. The clinical spectra range from
very aggressive metastatic disease to spontaneous regression, even without therapy …

Background Classification of pediatric tumors into biologically defined subtypes is
challenging, and multifaceted approaches are needed. For this aim, we developed a …

Although intratumoral heterogeneity has been established in pediatric central nervous
system tumors, epigenomic alterations at the cell type level have largely remained …

We explored the associations of aberrant DNA methylation patterns in 12 candidate genes
with adult glioma subtype, patient survival, and gene expression of enhancer of zeste …

Background Aberrant DNA methylation is a prominent feature of many cancers, and may be
especially relevant in germ cell tumors (GCTs) due to the extensive epigenetic …