MethLAB: a graphical user interface package for the analysis of array-based DNA methylation data
Recent evidence suggests that DNA methylation changes may underlie numerous complex
traits and diseases. The advent of commercial, array-based methods to interrogate DNA …
traits and diseases. The advent of commercial, array-based methods to interrogate DNA …
Frequent but borderline methylation of p16 INK4a and TIMP3 in medulloblastoma and sPNET revealed by quantitative analyses
J Mühlisch, T Bajanowski, CH Rickert… - Journal of Neuro …, 2007 - Springer
Certain risk groups among tumors of the central nervous system (CNS) in children take an
almost inevitably fatal course. The elucidation of molecular mechanisms offers hope for …
almost inevitably fatal course. The elucidation of molecular mechanisms offers hope for …
Clustering of gene hypermethylation associated with clinical risk groups in neuroblastoma
Background: Neuroblastoma is the most common extracranial solid malignancy in infancy
and childhood, but the biological factors involved in its development and progression are …
and childhood, but the biological factors involved in its development and progression are …
Prognostic significance of promoter DNA methylation in patients with childhood neuroblastoma
DT Lau, LB Hesson, MD Norris, GM Marshall… - Clinical Cancer …, 2012 - AACR
Purpose: To characterize the clinical significance of promoter methylation in a cohort of
primary neuroblastoma tumors and investigate the association between DNA methylation …
primary neuroblastoma tumors and investigate the association between DNA methylation …
DNA hypomethylation affects cancer-related biological functions and genes relevant in neuroblastoma pathogenesis
Neuroblastoma (NB) pathogenesis has been reported to be closely associated with
numerous genetic alterations. However, underlying DNA methylation patterns have not been …
numerous genetic alterations. However, underlying DNA methylation patterns have not been …
Distinguishing glioblastoma subtypes by methylation signatures
Glioblastoma, also called glioblastoma multiform (GBM), is the most aggressive cancer that
initiates within the brain. GBM is produced in the central nervous system. Cancer cells in …
initiates within the brain. GBM is produced in the central nervous system. Cancer cells in …
DNA methylation profiling of medulloblastoma allows robust subclassification and improved outcome prediction using formalin-fixed biopsies
Molecular subclassification is rapidly informing the clinical management of
medulloblastoma. However, the disease remains associated with poor outcomes and …
medulloblastoma. However, the disease remains associated with poor outcomes and …
DNA methylation in glioblastoma: impact on gene expression and clinical outcome
Background Changes in promoter DNA methylation pattern of genes involved in key
biological pathways have been reported in glioblastoma. Genome-wide assessments of …
biological pathways have been reported in glioblastoma. Genome-wide assessments of …
Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing
Epigenetic alterations, that is, disruption of DNA methylation and chromatin architecture, are
now acknowledged as a universal feature of tumorigenesis. Medulloblastoma, a clinically …
now acknowledged as a universal feature of tumorigenesis. Medulloblastoma, a clinically …
Identification of epigenetically regulated genes that predict patient outcome in neuroblastoma
H Carén, A Djos, M Nethander, RM Sjöberg, P Kogner… - BMC cancer, 2011 - Springer
Background Epigenetic mechanisms such as DNA methylation and histone modifications
are important regulators of gene expression and are frequently involved in silencing tumor …
are important regulators of gene expression and are frequently involved in silencing tumor …