Background DNA methylation is a major epigenetic modification important for regulating
gene expression and suppressing spurious transcription. Most methods to scan the genome …

Genome-wide mapping of epigenetic changes is essential for understanding the
mechanisms involved in gene regulation during cell differentiation and embryonic …

Background Array based methylation profiling is a cost-effective solution to study the
association between genome methylation and human disease & development. Available …

Methylation of promoter regions of CpG-rich sites is an important mechanism for silencing of
tumor suppressor genes (TSG). To evaluate the role of tumor suppressor genes caspase-8 …

Accurate assessment of neuroblastoma outcome prediction remains challenging. Therefore,
this study aims at establishing novel prognostic tumor DNA methylation biomarkers. In total …

DNA methylation is the most studied epigenetic mark and CpG methylation is central to
many biological processes and human diseases. Since cancer has highlighted the …

Differential methylation hybridization (DMH) is a high-throughput DNA methylation
screening tool that utilizes methylation-sensitive restriction enzymes to profile methylated …

Low-grade gliomas (LGGs) account for about a third of all brain tumours in children. We
conducted a detailed study of DNA methylation and gene expression to improve our …

An abnormal pattern of DNA methylation occurs at specific genes in almost all neoplasms.
The lack of high-throughput methods with high specificity and sensitivity to detect changes in …

Differential DNA methylation is an essential epigenetic signal for gene regulation,
development, and disease processes. We mapped DNA methylation patterns of 190 gene …