Low-grade gliomas (LGGs) account for about a third of all brain tumours in children. We
conducted a detailed study of DNA methylation and gene expression to improve our …

DNA methylation stabilizes developmentally programmed gene expression states. Aberrant
methylation is associated with disease progression and is a common feature of cancer …

Glioblastoma multiforme (GBM) is the most common, most invasive, and malignant type of
primary brain tumor with poor prognosis and poor survival rate. Using GSE22891 the …

Genetic and epigenetic alterations are essential for the initiation and progression of human
cancer. We previously reported that primary human medulloblastomas showed extensive …

An abnormal pattern of DNA methylation occurs at specific genes in almost all neoplasms.
The lack of high-throughput methods with high specificity and sensitivity to detect changes in …

Background The newly released 450k DNA methylation array from Illumina, Inc. offers the
possibility to analyze more than 480,000 individual CpG sites in a user friendly standardized …

Gliomas are tumors of the central nervous system with a wide spectrum of different tumor
types. They range from pilocytic astrocytoma, with a generally good prognosis, to the …

Glioblastoma multiforme (GBM) is the most frequent and devastating primary brain tumor in
adults. The presence of epigenetic lesions, like hypermethylation of known tumor …

Cytosine-5 DNA methylation occurs in the context of CpG dinucleotides in vertebrates.
Aberrant methylation of CpG islands in human tumors has been shown to cause …

DNA methylation has long been recognized as a tumor‐promoting factor when aberrantly
regulated in the promoter region of genes. However, the effect of intragenic DNA methylation …