Cytosine-5 DNA methylation occurs in the context of CpG dinucleotides in vertebrates.
Aberrant methylation of CpG islands in human tumors has been shown to cause …

Altered methylation patterns have been found to play a role in developmental disorders,
cancer and aging. Increasingly, changes in DNA methylation are used as molecular markers …

Abstract Analysis of DNA methylation patterns relies increasingly on sequencing-based
profiling methods. The four most frequently used sequencing-based technologies are the …

DNA methylation, the reversible addition of methyl groups at CpG dinucleotides, represents
an important regulatory layer associated with gene expression. Changed methylation status …

Recent advances in genomic technologies have allowed for tremendous progress in our
understanding of the biology underlying medulloblastoma, a malignant childhood brain …

We describe an optimized microarray method for identifying genome-wide CpG island
methylation called microarray-based methylation assessment of single samples (MMASS) …

Aberrant DNA methylation of CpG sites is among the earliest and most frequent alterations
in cancer. Several studies suggest that aberrant methylation occurs in a tumour type-specific …

Abstract Background Hypermethylation of promoter CpG islands is strongly correlated to
transcriptional gene silencing and epigenetic maintenance of the silenced state. As well as …

Epigenetic inactivation of tumor suppressor genes is a common feature in human cancer.
Promoter hypermethylation and histone deacetylation are reversible epigenetic mechanisms …

DNA methylation is essential for normal development,, and has been implicated in many
pathologies including cancer,. Our knowledge about the genome-wide distribution of DNA …