How does DNA methylation repress transcription?
… the repressive chromatin structure. Although we focus on molecular mechanisms that might
influence DNA methylation and gene expression in dividing cells, DNA demethylation is also …
influence DNA methylation and gene expression in dividing cells, DNA demethylation is also …
Role of DNA methylation in stable gene repression
L Lande-Diner, J Zhang, I Ben-Porath… - Journal of Biological …, 2007 - ASBMB
… DNA methylation on both gene expression and chromatin structure. Our results confirm that
the underlying methylation … that many methylated genes are subject to additional repression …
the underlying methylation … that many methylated genes are subject to additional repression …
DNA methylation and silencing of gene expression
J Newell-Price, AJL Clark, P King - Trends in Endocrinology & Metabolism, 2000 - cell.com
… DNA methylation is associated with the silencing of gene … The predominant mechanism
involves the methylation of DNA … repress the transcription of the genes encoding human DNA …
involves the methylation of DNA … repress the transcription of the genes encoding human DNA …
DNA methylation: the nuts and bolts of repression
TB Miranda, PA Jones - Journal of cellular physiology, 2007 - Wiley Online Library
… implicating DNA methylation in the silencing of germline specific genes (Weber et al., 2007).
By … at global DNA methylation, this study found a subset of genes that were methylated in …
By … at global DNA methylation, this study found a subset of genes that were methylated in …
DNA methylation
R Singal, GD Ginder - Blood, The Journal of the American …, 1999 - ashpublications.org
… Three possible mechanisms have been proposed to account for transcriptional repression
by DNA methylation, and each is shown in Fig 3. The first mechanism involves direct …
by DNA methylation, and each is shown in Fig 3. The first mechanism involves direct …
Repression of genes by DNA methylation depends on CpG density and promoter strength: evidence for involvement of a methyl‐CpG binding protein.
J Boyes, A Bird - The EMBO journal, 1992 - embopress.org
… of this sparsely methylated promoter was in fact … of DNA methylation on transcription of
CpG-deficient genes, using promoters of different strengths to gauge the severity of repression. …
CpG-deficient genes, using promoters of different strengths to gauge the severity of repression. …
[PDF][PDF] DNA methylation directs a time-dependent repression of transcription initiation
SU Kass, N Landsberger, AP Wolffe - Current biology, 1997 - cell.com
… Our results establish that HSV tk gene expression is regulated by DNA methylation at the
level of transcription (Fig. 1a), and more specifically at the initiation step (Fig. 1b), in a time-…
level of transcription (Fig. 1a), and more specifically at the initiation step (Fig. 1b), in a time-…
[引用][C] The essentials of DNA methylation
A Bird - cell, 1992 - Elsevier
… DNA methylation can stably repress transcription, it could be that repression is leaky in the
absence of DNA … One possible answer is based on the evidence that cytosine methylation in …
absence of DNA … One possible answer is based on the evidence that cytosine methylation in …
DNA methylation and the regulation of gene transcription
JT Attwood, RL Yung, BC Richardson - Cellular and Molecular Life …, 2002 - Springer
… Interestingly, MBD2 has been found in association with both Sin3A [113] and also the Mi2/NuRD
complex [112], and is likely to play a role in gene repression mediated by both Sin3A …
complex [112], and is likely to play a role in gene repression mediated by both Sin3A …
Molecular mechanisms of gene silencing mediated by DNA methylation
M Curradi, A Izzo, G Badaracco… - Molecular and cellular …, 2002 - Taylor & Francis
… does not represent the main mechanism by which methylation-mediated gene silencing
is exerted. In most cases, DNA methylation seems to repress gene expression by recruiting …
is exerted. In most cases, DNA methylation seems to repress gene expression by recruiting …
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