… the repressive chromatin structure. Although we focus on molecular mechanisms that might
influence DNA methylation and gene expression in dividing cells, DNA demethylation is also …

… DNA methylation on both gene expression and chromatin structure. Our results confirm that
the underlying methylation … that many methylated genes are subject to additional repression …

… DNA methylation is associated with the silencing of gene … The predominant mechanism
involves the methylation of DNA … repress the transcription of the genes encoding human DNA …

… implicating DNA methylation in the silencing of germline specific genes (Weber et al., 2007).
By … at global DNA methylation, this study found a subset of genes that were methylated in …

… Three possible mechanisms have been proposed to account for transcriptional repression
by DNA methylation, and each is shown in Fig 3. The first mechanism involves direct …

… of this sparsely methylated promoter was in fact … of DNA methylation on transcription of
CpG-deficient genes, using promoters of different strengths to gauge the severity of repression. …

… Our results establish that HSV tk gene expression is regulated by DNA methylation at the
level of transcription (Fig. 1a), and more specifically at the initiation step (Fig. 1b), in a time-…

… DNA methylation can stably repress transcription, it could be that repression is leaky in the
absence of DNA … One possible answer is based on the evidence that cytosine methylation in …

… Interestingly, MBD2 has been found in association with both Sin3A [113] and also the Mi2/NuRD
complex [112], and is likely to play a role in gene repression mediated by both Sin3A …

… does not represent the main mechanism by which methylation-mediated gene silencing
is exerted. In most cases, DNA methylation seems to repress gene expression by recruiting …