… on genes with a low density of methyl-CpG. We found thatsparse methylation could repress
transfected genes … Densely methylated genes, however, could not be reactivated by the …

… promoters are intrinsically less sensitive to LAD repression. This is not simply explained by
promoter strength but by the interplay between promoter … of gene regulation by repressive …

… One example is the repression of the promoters for the E. coli dnaA gene by oligomerization
… Indeed, promoter strength is known to be a compromise between efficient recognition by …

… promoter approach for controlling constitutive gene expression, we sought to apply our
approach to control promoter … element to P GAL further repressed gene expression levels by 7% …

… promoter strength of the regulated promoters used in this study. The LacZY genes on pNN387
lack a promoter… interfere with the expression of the aadA gene. The arrows in this diagram …

… repression later in this work. The direct correlation between these two measurements of gene
… vs average mRNA copy number for every promoter strength, exhibiting an excellent linear …

… and/or repression of a number of genes to adapt cell … of mechanisms to regulate gene
expression affecting virtually … The strength of a promoter relies on the combined efficiency …

… that a gene's promoter is a major determinant in cis for effective transcriptional repression
near … 2), we propose that repression is primarily exerted on the gene's promoter and therefore …

… We show that genes can be effectively repressed in multiplex format, and … promoters were
tested for both dCas9 and sgRNA and we found that a tightly repressed, low-strength promoter …

… by sequence-specific repressors to promoters of genes regulated by signals triggered by …
the reporter gene was lengthened in the dual repression constructs, the repression strength …