Signal amplification in living cells: a review of microRNA detection and imaging

H Peng, AM Newbigging, MS Reid, JS Uppal… - Analytical …, 2019 - ACS Publications
… strategies that are capable of signal amplification in living cells without the use of protein …
of amplification systems into living cells, generation and amplification of intracellular signals

Signal amplification technologies for the detection of nucleic acids: from cell-free analysis to live-cell imaging

T Fozooni, H Ravan, H Sasan - Applied biochemistry and biotechnology, 2017 - Springer
… those signal amplification-based … signal amplification-based detection strategies for nucleic
acids in vitro, and subsequently extend the methods to in situ (eg, cell lysates and fixed cells) …

DNA walker for signal amplification in living cells

A Yuan, H Xiao, F Yang, H Hao, X Wang, J Li… - TrAC Trends in …, 2023 - Elsevier
… processivity of DNA walker in live cells, self-catalytic assembly … application as signal
amplification tools in living cells. … on development of signal amplification tools for live cell imaging, …

Two-color imaging of microRNA with enzyme-free signal amplification via hybridization chain reactions in living cells

L Li, J Feng, H Liu, Q Li, L Tong, B Tang - Chemical Science, 2016 - pubs.rsc.org
amplifying and visualizing low levels of miRNA in living cells for the first time. The assay is
technologically easy to implement in living cells because the amplification … into living cells in a …

In situ amplification‐based imaging of RNA in living cells

Z Qing, J Xu, J Hu, J Zheng, L He, Z Zou… - Angewandte …, 2019 - Wiley Online Library
… Ultrasensitive in situ fluorescence imaging of mRNA expressed in living cells was
achieved with significant signal amplification. Afterwards, the Tang group developed a non-destructive …

Photoactivated DNA walker based on DNA nanoflares for signal-amplified microRNA imaging in single living cells

M Chen, R Duan, S Xu, Z Duan, Q Yuan, F Xia… - Analytical …, 2021 - ACS Publications
signal amplification miRNA-21 imaging in single living cells. The developed strategy combines
the previously developed photoactivated nucleic acid displacement reaction and the Exo …

A Graphene-enhanced imaging of microRNA with enzyme-free signal amplification of catalyzed hairpin assembly in living cells

H Liu, T Tian, D Ji, N Ren, S Ge, M Yan, J Yu - Biosensors and …, 2016 - Elsevier
… was amplified and imaged by proposed method in living cells in real … amplification and
thermal cycling is not needed. GO used as carrier can transport the DNA probes into living cells

Highly Sensitive Fluorescence Imaging of Zn2+ and Cu2+ in Living Cells with Signal Amplification Based on Functional DNA Self-Assembly

H Si, R Sheng, Q Li, J Feng, L Li, B Tang - Analytical chemistry, 2018 - ACS Publications
… a signal amplification strategy for the high-sensitivity detection and simultaneous in situ imaging
of Zn 2+ and Cu 2+ in living cells. … metal ions through signal amplification based on DNA …

… sensitive and homogeneous detection of membrane protein on a single living cell by aptamer and nicking enzyme assisted signal amplification based on microfluidic …

L Li, Q Wang, J Feng, L Tong, B Tang - Analytical chemistry, 2014 - ACS Publications
… single living cells by aptamer and nicking enzyme assisted fluorescence signal amplification
… The microfluidic system provides a high-throughput platform for the detection of a single cell

Dual-signal amplification strategy based on Catalytic Hairpin Assembly and APE1-assisted amplification for high-contrast miRNA imaging in living cells

Y Zhang, M Sun, J Xie, J Chen, T Huang… - Analytical …, 2024 - ACS Publications
… of CHA is hindered due to its low amplification efficiency and low tumor recognition contrast.
… dual-signal amplification strategy based on CHA and APE1-assisted amplification, enabling …