Variation, patterns, and temporal stability of DNA methylation: considerations for epigenetic epidemiology

RP Talens, DI Boomsma, EW Tobi, D Kremer… - The FASEB …, 2010 - Wiley Online Library
… to perform epigenetic association studies. We characterized features of DNA methylation at
16 … To test whether DNA methylation in blood could mark that in other tissues, we studied …

Major and essential role for the DNA methylation mark in mouse embryogenesis and stable association of DNMT1 with newly replicated regions

S Takebayashi, T Tamura, C Matsuoka… - Molecular and cellular …, 2007 - Taylor & Francis
… cells revealed that preexisting DNA methylation is a major determinant … stable association
with unmethylated chromatin. Our results reveal essential roles for the DNA methylation mark

Temporal stability and determinants of white blood cell DNA methylation in the breakthrough generations study

JM Flanagan, MN Brook, N Orr, K Tomczyk… - … Biomarkers & Prevention, 2015 - AACR
… We aimed to identify stable variable methylated probes (VMP), ie, markers that are variable
… reported stable methylation changes associated with smoking in white blood cell (WBC) DNA

DNA methylation alterations exhibit intraindividual stability and interindividual heterogeneity in prostate cancer metastases

MJ Aryee, W Liu, JC Engelmann, P Nuhn… - Science translational …, 2013 - science.org
… analyses of DNA methylation alterations in lethal metastatic prostate cancer and created DNA
methylation “… We show that somatic DNA methylation alterations, despite showing marked

[HTML][HTML] Long-term temporal stability of peripheral blood DNA methylation profiles in patients with inflammatory bowel disease

V Joustra, AYFL Yim, I Hageman, E Levin… - Cellular and Molecular …, 2023 - Elsevier
… we observed a marked stability of … stable DNA methylation in PBLs obtained from a well-generalizable
cohort of adult patients with IBD with a 7-year median time between collected DNA

Heritable DNA methylation marks associated with susceptibility to breast cancer

JE Joo, JG Dowty, RL Milne, EM Wong… - Nature …, 2018 - nature.com
… tested some of the most heritable methylation marks for association with breast cancer. Note
… , at least partially due to periconceptional environment and is stable for at least 10 years 35 . …

Genomic patterns of DNA methylation: targets and function of an epigenetic mark

M Weber, D Schübeler - Current opinion in cell biology, 2007 - Elsevier
… patterns at regulatory regions are generally stable, but a minor subset … DNA methylation on
a genome-wide scale have given new insights into the biological function of DNA methylation

Factors underlying variable DNA methylation in a human community cohort

LL Lam, E Emberly, HB Fraser… - Proceedings of the …, 2012 - National Acad Sciences
… , DNA methylation constitutes a main component of the epigenome, and it is considered the
most stable and accessible epigenetic mark … exploring associations of DNA methylation with …

Seasonal stability and dynamics of DNA methylation in plants in a natural environment

T Ito, H Nishio, Y Tarutani, N Emura, MN Honjo… - Genes, 2019 - mdpi.com
DNA methylation at cytosine residues is an epigenetic mark that can be maintained through
cell divisions in a wide range of eukaryotic genomes [1]. The previous analyses in diverse …

Biological stability of DNA methylation measurements over varying intervals of time and in the presence of acute stress

AT Apsley, Q Ye, L Etzel, S Wolf, WJ Hastings… - Epigenetics, 2023 - Taylor & Francis
… = 192), we report the stability of biological replicates over a variety of … the stability of repeated
DNA methylation measurements. In the absence of acute stress, probes were less stable as …