DNA methylation in stem cell renewal and multipotency

M Berdasco, M Esteller - Stem cell research & therapy, 2011 - Springer
… of stem cells in adult somatic cells. In this review, we focus on the role of DNA methylation in
… genes important for self-renewal, the dynamism of CpG methylation of tissue-specific genes …

DNA methylation and hydroxymethylation in stem cells

Y Cheng, N Xie, P Jin, T Wang - Cell biochemistry and function, 2015 - Wiley Online Library
… modifications and DNA methylation, particularly in stem cell function and differentiation. …
stem cells are undifferentiated cells that can differentiate into specialized cells and self-renew

DNA methylation in adult stem cells: New insights into self-renewal

JJ Trowbridge, SH Orkin - Epigenetics, 2010 - Taylor & Francis
… This suggests that in somatic stem cells, regulation of transcription by DNA methylation
both … to stem cell selfrenewal and silencing of differentiation programs through repeated cell

DNA methylation in embryonic stem cells

G Altun, JF Loring, LC Laurent - Journal of cellular biochemistry, 2010 - Wiley Online Library
… In this review, we will give an overview of the existing methods for studying DNA methylation,
and review the key DNA methylation studies specific to ESCs, with an emphasis on reports …

DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction

AM Bröske, L Vockentanz, S Kharazi, MR Huska… - Nature …, 2009 - nature.com
… is silenced to allow CSC renewal. In summary, DNA methylation is an important epigenetic
… programs in stem cells as a prerequisite to maintaining self-renewal and multipotency. …

Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging

I Beerman, C Bock, BS Garrison, ZD Smith, H Gu… - Cell stem cell, 2013 - cell.com
DNA methylation in these rare stem cells during ontogeny. We show that DNA methylation
… , total replicative potential, and differential DNA methylation are dependent on the divisional …

Effect of aberrant DNA methylation on cancer stem cell properties

Z Mazloumi, R Farahzadi, A Rafat, KD Asl… - Experimental and …, 2022 - Elsevier
… properties such as self-regeneration, resistance to … DNA methylation accumulation affects
self-renewal, differentiation, multidrug-resistant, and metastasis processes in cancer stem cells. …

The dynamics of DNA methylation fidelity during mouse embryonic stem cell self-renewal and differentiation

L Zhao, M Sun, Z Li, X Bai, M Yu, M Wang… - Genome …, 2014 - genome.cshlp.org
… To investigate the DNA methylation inheritance during ES cell fate commitment, we … data
for the self-renewal and spontaneous differentiating mouse ES-E14TG2a cells (denoted as E14-…

[HTML][HTML] DNA methylation and demethylation link the properties of mesenchymal stem cells: regeneration and immunomodulation

TY Xin, TT Yu, RL Yang - World journal of stem cells, 2020 - ncbi.nlm.nih.gov
… tissue regeneration and immunomodulation requires further investigation. In this review, we
discuss how DNA methylation and demethylation function in multi-lineage cell differentiation …

Characterization of DNA methylation change in stem cell marker genes during differentiation of human embryonic stem cells

S Yeo, S Jeong, J Kim, JS Han, YM Han… - … and biophysical research …, 2007 - Elsevier
… , REX1 and FOXD3, undergo significant methylation during hESCs differentiation in which …
rapidly by DNA methylation. Accordingly, we propose that the DNA methylation states of OCT4 …