[HTML][HTML] DNA methylation in stem cell renewal and multipotency

M Berdasco, M Esteller - Stem cell research & therapy, 2011 - Springer
stem cells could be restricted by the gain of DNA methylation of self-renewal genes (preventing
the undifferentiated features of stem cells in adult somatic cells) and the DNA methylation

DNA methylation and hydroxymethylation in stem cells

Y Cheng, N Xie, P Jin, T Wang - Cell biochemistry and function, 2015 - Wiley Online Library
… the function of embryonic stem cells and adult stem cells (such as haematopoietic stem
cells, neural stem cells and germline stem cells), and changes in DNA methylation patterns are …

DNA methylation in embryonic stem cells

G Altun, JF Loring, LC Laurent - Journal of cellular biochemistry, 2010 - Wiley Online Library
… In this review, we will give an overview of the existing methods for studying DNA methylation,
and review the key DNA methylation studies specific to ESCs, with an emphasis on reports …

[PDF][PDF] DNA methylation dynamics during in vivo differentiation of blood and skin stem cells

C Bock, I Beerman, WH Lien, ZD Smith, H Gu, P Boyle… - Molecular cell, 2012 - cell.com
DNA methylation during in vivo differentiation remain underexplored. Here we report high-resolution
DNA methylation maps of adult stemDNA methylation changes were locus specific …

[HTML][HTML] DNA methylation dynamics in human induced pluripotent stem cells over time

K Nishino, M Toyoda, M Yamazaki-Inoue… - PLoS …, 2011 - journals.plos.org
DNA methylation profiles To investigate the dynamics of DNA methylation in pluripotent
stem cells, we examined 5 ESC lines (HUESCs) [23], [24], 22 iPSC lines, their parent cells and …

Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer

AE Teschendorff, U Menon, A Gentry-Maharaj… - Genome …, 2010 - genome.cshlp.org
… be reflected in multipotent progenitor and stem cell pools. To this end, we investigated the
DNA methylation profiles of cultured mesenchymal stromal/stem cells (MSC) derived from the …

[PDF][PDF] Recurrent variations in DNA methylation in human pluripotent stem cells and their differentiated derivatives

KL Nazor, G Altun, C Lynch, H Tran, JV Harness… - Cell stem cell, 2012 - cell.com
… For these analyses, we identified 214 CpGs on the 450K DNA Methylation array that had
DNA methylation patterns consistent with gametic imprinting according to patterns observed in …

[PDF][PDF] Dynamic heterogeneity and DNA methylation in embryonic stem cells

ZS Singer, J Yong, J Tischler, JA Hackett, A Altinok… - Molecular cell, 2014 - cell.com
… Finally, using perturbations, we observed that DNA methylation modulates the population
fraction of cells in the two states, consistent with reciprocal expression of the methyltransferase …

Pluripotent stem cells escape from senescence-associated DNA methylation changes

CM Koch, K Reck, K Shao, Q Lin, S Joussen… - Genome …, 2013 - genome.cshlp.org
… evade replicative senescence, whereas other primary cells lose their … DNA methylation
(SA-DNAm) changes. Here, we investigate SA-DNAm changes in mesenchymal stromal cells (…

DNA methylation on N6-adenine in mammalian embryonic stem cells

TP Wu, T Wang, MG Seetin, Y Lai, S Zhu, K Lin, Y Liu… - Nature, 2016 - nature.com
… the only form of DNA methylation in mammalian genomes. Here we identify N 6 -methyladenine
as another form of DNA modification in mouse embryonic stem cells. Alkbh1 encodes a …