… can be reprogrammed, we considered a specific example: reprogramming the cell to
transition from the endoderm lineage to the stem cell state. We found that activating Nanog is a …

… the most pluripotent stem cells known: embryonic stem (ES) cells. However, ES cells are not
… The trophectoderm and primitive endoderm lineages also provide the first signals that drive …

… on directing hES cells to the definitive endoderm lineage as this step is a prerequisite for
efficient differentiation to mature endoderm derivatives. Differentiation of hES cells in the …

… To gain insight into endodermal lineage commitment mecha… across multiple steps of
endoderm induction and patterning. … endoderm competence is preconfigured in pluripotent cells. …

… required for ES cells to perceive a cell positioning (cell aggregation) … stem cells in their
determination of endoderm lineage. This study indicates that the lineage differentiation of ES cells …

… of both mesoderm- and endoderm-fated cells. Having shown … -like cells to either mesoderm
or definitive endoderm lineages. … hESC differentiation toward definitive endoderm and larger …

… stem cell differentiation should be based on knowledge of the mechanisms by which lineage
… the trophectoderm or visceral endodermal lineages by ES cells has not been demonstrated. …

… endoderm is the cellular … Endodermal lineage cells derived from pluripotent stem cells (PSCs)
in vitro are a potentially unlimited resource for regenerative medicine. These cells are …

… that lineage development is dependent on the concentration of factor used. Using an ES cell
… the endoderm lineage develops from a brachyury + population with mesoderm potential. …

… , suggesting the capacity to form these multiple endodermal lineages. … , clonal
endoderm-committed stem cell lines from human ESCs and iPSCs. These cells, termed EP cells, can …