… of differentiated cell types in vitro. To address these issues, we established endodermal
progenitor (EP) cell lines from human embryonic and induced pluripotent stem cells. Optimized …

… FACS-purified progenitors using a Nkx2–1-GFP mouse ES cell reporter line expressed
markers of mature proximal (CC10 + , Foxj1 + ) and distal (SPC + , T1α + ) lung as well as thyroid (…

… To assay whether constitutive expression of lineage-determining transcription factors in
HESC cells could promote the differentiation of endoderm-specific progenitors, cell lines …

… of endoderm-committed stem cell lines generated from human ESCs and iPSCs has
been described ([44 •• ] and Figure 1). These cells, termed endodermal progenitor (EP) cells, …

… ES cell line with the GFP cDNA targeted to the brachyury locus (Fehling et al., 2003),we provide
evidence that the endoderm … , suggesting that it derives from a mesendoderm progenitor. …

… to generate progenitor or precursor cells, which then differentiate or develop into “mature” …
enchyme, and gastric stem cells and in some undifferentiated carcinoma cell lines, whereas …

… streak (progenitor to endoderm), yet, 24 hr later, suppressed … multiple hPSC lines exclusively
into endoderm and its derivatives. … pure endodermal populations revealed that endodermal …

… To test the hypothesis, we cocultured mouse embryonic stem (ES) cells with the endodermal
cell line End2 by co-aggregation or End2-conditioned medium. Co-aggregation resulted in …

… Endodermal lineage cells derived from pluripotent stem cells (PSCs) in vitro are a potentially
… Self-renewing endodermal progenitor lines generated from human pluripotent stem cells. …

… We report that populations and clonal lines of MSCs express germline, ectodermal,
endodermal, and mesodermal genes, allowing far broader potential than expected. In turn, neural …