… transformation into malignant cells. We clearly demonstrated the process from stem cells to
malignant cells. … the origin of cancer stem cells are related to postnatal stem cells, there has …

… We conclude that spontaneous malignant transformation may … transformation process may
represent a unique model for studying molecular pathways initiating malignant transformation …

… stem cells are critical to tissue repair, several studies indicate that they also may have important
roles in malignant transformation … originate from bone marrow–derived cells (3), and that …

… No immortalization or malignant transformation was observed in the present study, which …
Spontaneous malignant transformation of human mesenchymal stem cells reflects cross-…

… unknown at which stage the malignant transformation occurs. It was … cells with the
immunophenotype of pluripotent stem cells in the leukemic process by the use of cytogenetic and …

… of stem cell population dynamics may be critical to acquisition of cancer phenotype. We tested
the hypothesis that prostate stem cells have … and facilitates their malignant transformation. …

… malignant transformation [27]. Comparative genomic hybridization analysis of stem cells …
presence could explain why p53 inactivation facilitates stem cell reprogramming [28]. This is …

… stem cells presumably allows for the acquisition of mutations that transform the preleukemic
cells to malignant cells… predisposing cells to leukemia and enabling the selection of cells that …

… capacity of adult stem/progenitor cells may allow them to … and malignant transformation into
cancer stem cells (CSCs) … tumorigenic cancer cells or their malignant progenies endowed …

… cancer stem cells remains rudimentary, the existence of such cells has implications for
current conceptualizations of malignant transformation and therapeutic approaches to cancer. …