… , it tells us something new about what self-renewal really is and what it requires at a … known
about stem cell self-renewal in a conceptual framework that addresses how stem cells persist …

… intestinal stem cell marker, it is now possible to visualize stem cells … stem cells. We also
discuss genetic studies that have helped to elucidate those signals important for progenitor cells …

… of myeloerythroid cells, and (2) the ability to self-replicate.5-8 a These findings introduced
the two defining criteria of stem cells ie, multipotency and self-renewal. HSCs are the only cells …

… cell to a self-renewing stem cell, or might prompt a stem cell to differentiate, divide or lose the
ability to self-renew… differentially affect cell proliferation and neural stem cell self-renewal in …

… those of the mother cell (Figure 1). The ability of stem cells to self-renew extensively is central
… Despite the importance of stem cell self-renewal, we are only beginning to understand how …

… stem cells and indicate that stem cell–like self-renewal mechanisms may be activated in mature
differentiated cells… in stem cells and whether they might be activated in other cell types as …

… )-positive undifferentiated cells remaining over 90%. As a rigorous test of the sufficiency of
3i to sustain ES-cell self-renewal, we examined the clonogenicity of isolated cells. After single-…

… Self-renewal is essential for stem cells because it is required for all stem cells to perpetuate
themselves. Neural stem cells are a subset of undifferentiated precursors that retain the …

… of stem cell self-renewal is of great biological and medical interest. In particular, adult tissue
stem cells must balance stem cell self-renewal … The cell cycle of embryonic stem (ES) cells is …

… to maintain the pool of undifferentiated cells or they can differentiate into specialized cell
lineages. … and mechanisms of adult stem cell self‐renewal. Concept of stem cell self‐renewal …