… Small ubiquitin-like modifiers (SUMO) conjugation to cellular … The SUMO proteases (SENP)
deconjugate modified proteins … SUMO homeostasis and contributes to cancer development …

… Results of studies indicate the role of SUMO proteases in the development of human diseases
including cancer, suggesting that these proteins may be attractive targets for new drugs. …

… SUMO-specific activating (E1), conjugating (E2) and ligating (E3) enzymes, and is reversed
by a family of Sentrin/SUMO-specific proteases … in placental development and erythropoiesis. …

… Prior to their conjugation, SUMO proteins need to be proteolytically processed … SUMO
specific proteases (SENPs) are cysteine proteases that cleave the pro or inactive form of SUMO at …

… Thus, it is of great need to develop novel diagnostic and therapeutic strategies to reduce the
… Sentrin/SUMO-specific protease 1 (SENP1) is a member of SUMO-specific protease family (…

… SUMO system is also involved in cancer metastasis. In this review, we will summarize and
discuss the possible role of SUMO system in cancer development … distinct SUMO proteases …

… ) is translated into a precursor form that must be processed by a SUMO protease before
SUMO can be conjugated to other proteins. Mature SUMO is conjugated to proteins in an ATP-…

… for normal growth and development in all … two SUMO proteases in yeast and six SUMO
proteases in humans, it seems likely that these proteases have evolved to carry out specific SUMO…

… function of USPL1 in Cajal bodies described to date is independent of its SUMO protease
activity [ … of polycomb group protein-mediated gene silencing during embryonic development. …

… SUMO-specific proteases (SENPs) are cysteine proteases with isopeptidase activity … ’
aberrant expression is associated with the development and progression of cancer. In this review, …