… for de novo methylation, as they are able to target unmethylated CpG sites [5]. They also
cooperate with DNMT1 to propagate methylation patterns during cell division [6]. DNMT2 has …

… The role of functional genomics in modern drug discovery is to prioritize these targets and to
… Here, we describe the field of functional genomics and review approaches that have been …

… The target cDNA is first labeled using fluorescent dyes and then hybridized to the array surface.
The retained labeled target … Human tumor samples frequently show abnormal patterns of …

… in genomes of individuals. Our work highlights a widespread pattern in how gene function is
… , respectively (the “/Par” denotes that parent GO terms of the target functions were removed). …

… in mammalian target genes. Of note, around one third of known human target genes … for
formulating hypotheses regarding the overall genomic expression pattern. Surprisingly, limited …

… Kinases play key roles in cell signaling and represent major targets for drug development, …
genes were transcriptionally active led to a functional genomic taxonomy of the kinome and a …

… , indicating potential broad therapeutic implications of targeting CSNK1e function. In summary,
through a functional genomics approach, pathways essential in the context of oncogenic …

… mediated epigenetic regulation to understand how they dynamically target genes within
the genome during stem cell differentiation and neuronal activity-dependent cellular events. …

… the target gene by virtue of being intertwined with the target gene's … gene after whole-genome
duplication and subsequent … The functions and expression patterns of bystander genes …

… genomic DNA methylation maps during cellular differentiation at unprecedented resolution.
Combined with functional … an important role in shaping methylation patterns. This tightly links …