… Since SAM might have effects other than increasing DNA methylation, we tested whether the
antimetastatic effects of SAM are reversible by the DNA demethylating agent 5-za-CdR. The …

… progress in using DNA methylation inhibitors in cancer therapy and the potential … DNA
hypermethylation in cancer and in providing the proof of principle for DNA demethylation therapy …

… DNA demethylation agents cause activation of metastatic genes. The methylation status
of metastatic genes such as uPA, is in steady state equilibrium, which is a balance of …

… In this article, the biological rationale for targeting aberrant methylation in cancer therapy
is reviewed and completed phase I and II trials of this approach, some of which show promise …

… DNA demethylation may have significant therapeutic … DNA demethylase targeted to the
tumor suppressor gene promoter CpG sites can be made by fusing human TET1 demethylase …

… DNA hypomethylation aberrations play in metastasis and its potential therapeutic implications…
oligonucleotide directed against the putative DNA demethylase MBD2 results in silencing …

… DNA demethylation by modifying or removing 5mC. In contrary, passive DNA demethylation
… results in dilution and loss of 5mC during DNA replication (Wu & Zhang, 2010) (Fig. 2). …

… of DNA demethylation, the presence of active demethylation in … An interesting therapeutic
implications of the global … might turn into a new approach to cancer therapy [117]. It is clear …

… "bear a general DNA demethylase activity that is similar to the DNA methyltransferase. This
… the therapeutic implications of DNA methylation. First, because the level of DNA methyl…

… it is expected to have the general nucleoside analog side effects of DAC, its favorable
pharmacokinetic properties make it a good candidate for a therapeutic DNA demethylating agent. …