DNA methylation as a therapeutic target in cancer
JPJ Issa - Clinical Cancer Research, 2007 - AACR
… by DNA methylation makes this specific therapeutic target … of oncogenes silenced in cancer
by DNA methylation (15) and … Nevertheless, a therapeutic ratio for hypomethylation therapy …
by DNA methylation (15) and … Nevertheless, a therapeutic ratio for hypomethylation therapy …
The DNA methylation machinery as a therapeutic target
M Szyf - Current Drug Targets, 2000 - ingentaconnect.com
… important therapeutic advantage. This review argues that DNA methylation plays an important
role in the control of genomic processes, suggests how the DNA methylation machinery is …
role in the control of genomic processes, suggests how the DNA methylation machinery is …
DNA methylation as a diagnostic and therapeutic target in the battle against Type 2 diabetes
… the genome-wide DNA methylation pattern in human pancreatic islets obtained from
deceased donors [Citation13]. We found altered levels of DNA methylation in islets from Type 2 …
deceased donors [Citation13]. We found altered levels of DNA methylation in islets from Type 2 …
[HTML][HTML] DNA methylation as a therapeutic target for bladder cancer
… a putative target for anti-cancer therapy [24,25]. The main goal of this review is to summarize
the impact of aberrant DNA methylation in BC, focusing on therapeutic strategies that target …
the impact of aberrant DNA methylation in BC, focusing on therapeutic strategies that target …
[HTML][HTML] DNA methylation as a future therapeutic and diagnostic target in rheumatoid arthritis
M Ciechomska, L Roszkowski, W Maslinski - Cells, 2019 - mdpi.com
… Thus, epigenetic therapies controlling autoimmunity and systemic inflammation may find …
targeting DNA methylation may improve diagnostic, prognostic, and therapeutic approaches. …
targeting DNA methylation may improve diagnostic, prognostic, and therapeutic approaches. …
Targeting DNA methylation
JPJ Issa, HM Kantarjian - Clinical Cancer Research, 2009 - AACR
… therapy and how to move it from life extension to cure. The epigenetic potential of DNA
methylation … that are also worth exploring as therapeutic targets. But the idea of stably changing …
methylation … that are also worth exploring as therapeutic targets. But the idea of stably changing …
Targeting DNA methylation for epigenetic therapy
… of DNA methylation and other … DNA methylation an excellent target for anticancer therapies.
During the last few decades, an increasing number of drugs targeting DNA methylation have …
During the last few decades, an increasing number of drugs targeting DNA methylation have …
Readers of DNA methylation, the MBD family as potential therapeutic targets
GD Ginder, DC Williams Jr - Pharmacology & Therapeutics, 2018 - Elsevier
… methylated and silenced genes. In this review, we discuss the role of DNA methylation in …
, and the possibility of targeting the complexes these proteins form to treat human disease. …
, and the possibility of targeting the complexes these proteins form to treat human disease. …
DNA methylation: a promising target for the twenty-first century
PA Abreu, G Dellamora-Ortiz… - … on therapeutic targets, 2008 - Taylor & Francis
… Due to the key role of methylation in many physiological (ie, … briefly review the DNA methylation
process catalyzed by DNA … of DNA methylation and its potential as a therapeutic target. …
process catalyzed by DNA … of DNA methylation and its potential as a therapeutic target. …
DNA methylation as a pathogenic event and as a therapeutic target in AML
T Schoofs, C Müller-Tidow - Cancer treatment reviews, 2011 - Elsevier
… DNA methylation strongly interacts with other components of the epigenetic machinery such
as histone modifications, aberrant DNA methylation … ), aberrations of DNA methylation also …
as histone modifications, aberrant DNA methylation … ), aberrations of DNA methylation also …
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