… of means to manipulate the splicing cascade for therapeutic purposes. In this Review, we
highlight the current and developing strategies to target aberrant splicing events, as well as …

… Splicing, both constitutive and regulated forms, can itself be targeted by conventional and
molecular therapies. This review focuses on splicing as a therapeutic target with a particular …

… splicing has been proposed as a potential therapy in cancer. To identify and validate aberrant
RNA splicing patterns as therapeutic targets we … of the spliceosome and of splice sites, (2) …

… or therapeutic resistance. Here, we review normal splicing mechanisms and splicing …
factors highlights these mutations as exciting therapeutic targets. To date, however, there …

… importance of splicing has proved that splicing reactions are potential therapeutic targets. …
) that interferes with exonic splicing enhancer activity of the SR protein splicing factor SF2/ASF …

… splicing related to cancer and the associated therapeutic … biomarkers and develop new
therapeutic strategies. This review … splicing associated with cancer and the targeted therapeutic …

… Thus, dysregulation of alternative RNA splicing is fundamental to cancer and provides a
potentially rich source of novel therapeutic targets. Here, we review the alterations in splicing …

… to the renatured protein, and then 5 mm EDTA and 2 mm tris(2-carboxyethyl)phosphine were
added to the solution to trigger the protein splicing. Protein splicing was also monitored on …

… In particular, examination of the mechanisms of regulation of the latter three processes is
revealing well-founded novel therapeutic targets against chronic infections by tumour viruses. …

… Prior studies have attempted to identify causes or potential therapeutic targets via disease-related
alternative splicing analyses. A recently discovered structural splicing enhancer (SSE) …