… While the initial DNAdamage may be repaired, the epigenetic change can … in tumor promotion
is compatible with the notion that reversibility is a fundamental component of the promotion …

… promotion, being interruptible or reversible, was believed to be caused by epigenetic
mechanisms… by genetic instability that led to mutagenic and epigenetic changes). In addition, …

… The testing of this hypothesis can serve as a focal point for a mechanism of action-… epigenetic
events, species-to-species extrapolation/unique species sensitivity, tumor promotion, and …

… the human body, epigenetic mechanisms, through reversible … resulting in a dynamic
heterogeneous tumor cell population. … the role of tumor cell epigenomes in mechanisms …

… during the development of tumors (2). Epigenetic mechanisms of tumor cell growth and gene
… regulate the expression of some genes to promote tumor metastasis. For example, DNMT1 …

… Epigenetic alterations occur in an unsystematic way or as part of aberrant transcriptional
machinery, promoting selective advantage to the tumor … different epigenetic mechanisms in oral …

… the role of epigenetic mechanisms in the control and regulation of tumor angiogenetic … of
VEGFR-2 and endothelial nitric oxide that further promote angiogenesis.21 Higher levels of HIF-…

… ), is to increase tumor cell numbers by promoting cell … promoting carcinogenesis. In one
study, increased Survivin expression was associated with a more aggressive and invasive tumor …

… to obtain the neoplastic phenotype by either a mutagenic or epigenetic mechanism (10).
Despite the highly malignant nature of teratocarcinomas, it is possible that induction of these …

… Epigenetic silencing of tumor suppressor genes promotes … levels, ostensibly through
non-epigenetic mechanisms. … There are several possible mechanisms by which proteases …