… unselected CpG islands in each of 98 primary human tumours … We estimate that an average
of 600 CpG islands (range of 0 … methylated in the tumours, including early stage tumours. We …

… tumour type. This was most apparent in colon cancer, where it was shown that sporadic
tumours with … Remarkably, parallel studies established that these MSI-positive tumours also had …

… to specific tumour types, but rather that concordant aberrant DNA methylation can be a
general phenomenon in cancer, but involve different genes depending on the tumour type. …

… 5' CpG island methylation of p16 in cancer cell lines We analysed the S' CpG island of p16
for changes in DNA methylation. As expected", the SmaI and SacII sites were unmethylated in …

… other tumour types has rapidly expanded. Concordant and widespread hypermethylation
of multiple CpG islands … and treatments of solid tumours. However, studies on CIMP in solid …

… in tumours there are on average 600 CpG islands aberrantly … tumour types and within
particular histological sub-types (… are CpG islands that are methylated in multiple tumour types, …

… An interesting example is CDKN2A which is frequently hypermethylated in a variety of tumour
types [99]. CDKN2A is normally only expressed in cells following replicative or oncogenic …

… CpG islands of tumour suppressor genes is thought to be an important mechanism in human
carcinogenesis. A number of tumour … 4 CpG island methylation has been found in colorectal …

… tumours there are, on average, 600 CpG islands aberrantly methylated, although this can
vary widely between tumour types … CpG islands are consistently methylated in several tumour …

… In the present study we investigated possible associations between MTHFR genotype
and tumour specific methylation at CpG islands. Because of the relatively small numbers, …