[HTML][HTML] Universal DNA methylation age across mammalian tissues

AT Lu, Z Fei, A Haghani, TR Robeck, JA Zoller, CZ Li… - Nature aging, 2023 - nature.com
… , can be accurately estimated using DNA methylation profiles, the foundation of pan-… universal
pan-mammalian clocks, using 11,754 methylation arrays from our Mammalian Methylation

Universal DNA methylation age across mammalian tissues

AT Lu, Z Fei, A Haghani, TR Robeck, JA Zoller, CZ Li… - BioRxiv, 2021 - biorxiv.org
… in highly-conserved stretches of DNA, from 59 tissue-types derived … methylation profiles,
we constructed three age predictors, each with a single mathematical formula, termed universal

Universal DNA methylation age across mammalian tissues

Z Fei, K Raj, S Horvath - Innovation in Aging, 2021 - europepmc.org
… the methylation profiles of these age-related cytosines, we successfully constructed three
highly accurate universal … From the methylation profiles of these age-related cytosines, we …

A multi-tissue age prediction model based on DNA methylation analysis

H Alsaleh, NA McCallum, DL Halligan… - Forensic Science …, 2017 - Elsevier
universal DNA methylation markers across forensically relevant tissues. By using elastic net
regression, it was possible to identify 10 age-related (AR) DNA methylation … multi-tissue age

[HTML][HTML] DNA methylation age of human tissues and cell types

S Horvath - Genome biology, 2013 - Springer
… I propose that DNA methylation age measures the cumulative effect of an epigenetic
maintenance system. This novel epigenetic clock can be used to address a host of questions in …

[HTML][HTML] Multi-tissue DNA methylation age predictor in mouse

TM Stubbs, MJ Bonder, AK Stark, F Krueger… - Genome biology, 2017 - Springer
… We find that discrete DNA methylation changes correlate with chronological age and are
associated with biological functions. Based on these findings, we generated a multi-tissue age

Trends in DNA methylation with age replicate across diverse human populations

S Gopalan, O Carja, M Fagny, E Patin, JW Myrick… - Genetics, 2017 - academic.oup.com
… world; it is not known if age-related patterns of DNA methylation at these loci are similar across
… genome-wide methylation patterns using saliva- and whole blood-derived DNA from two …

DNA methylation-based age clocks: From age prediction to age reversion

R Noroozi, S Ghafouri-Fard, A Pisarek… - Ageing Research …, 2021 - Elsevier
… in this review including epigenetic age estimator (epigenetic age clock), epigenetic age (DNA
methylation age), phenotypic age, and epigenetic age acceleration are defined as follows. …

Identification and evaluation of age-correlated DNA methylation markers for forensic use

JL Park, JH Kim, E Seo, DH Bae, SY Kim… - Forensic Science …, 2016 - Elsevier
… (±6 years) with accuracy of 77.30% in the <60 years age group … our three DNA methylation
markers may be useful for ageuniversal DNA methylation markers that can be used for age

DNA methylation as a universal biomarker

VV Levenson - Expert review of molecular diagnostics, 2010 - Taylor & Francis
… of DNA methylation-based biomarkers. A number of excellent reviews have been published
recently on methylation and … Besides cancer, DNA methylation also appears to be useful for …